Role of Endothelial Cell–Derived Angptl2 in Vascular Inflammation Leading to Endothelial Dysfunction and Atherosclerosis Progression | Zendy

Eiji Horio | Zendy; Tsuyoshi Kadomatsu | Zendy; Keishi Miyata | Zendy; Yasumichi Arai | Zendy; Kentaro Hosokawa | Zendy; Yasufumi Doi | Zendy; Toshiharu Ninomiya | Zendy; Haruki Horiguchi | Zendy; Motoyoshi Endo | Zendy; Mitsuhisa Tabata | Zendy; Hirokazu Tazume | Zendy; Zhe Tian | Zendy; Otowa Takahashi | Zendy; Kazutoyo Terada | Zendy; Motohiro Takeya | Zendy; Hiroyuki Hao | Zendy; Nobuyoshi Hirose | Zendy; Takashi Minami | Zendy; Toshio Suda | Zendy; Yutaka Kiyohara | Zendy; Hisao Ogawa | Zendy; Koichi Kaikita | Zendy; Yuichi Oike | Zendy

Open Access

Role of Endothelial Cell–Derived Angptl2 in Vascular Inflammation Leading to Endothelial Dysfunction and Atherosclerosis Progression

Author(s) -

Eiji Horio,

Tsuyoshi Kadomatsu,

Keishi Miyata,

Yasumichi Arai,

Kentaro Hosokawa,

Yasufumi Doi,

Toshiharu Ninomiya,

Haruki Horiguchi,

Motoyoshi Endo,

Mitsuhisa Tabata,

Hirokazu Tazume,

Zhe Tian,

Otowa Takahashi,

Kazutoyo Terada,

Motohiro Takeya,

Hiroyuki Hao,

Nobuyoshi Hirose,

Takashi Minami,

Toshio Suda,

Yutaka Kiyohara,

Hisao Ogawa,

Koichi Kaikita,

Yuichi Oike

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.303116

Subject(s) - proinflammatory cytokine , inflammation , endothelial dysfunction , endothelium , endothelial stem cell , endothelial activation , vascular permeability , medicine , foam cell , monocyte , macrophage , immunology , pathology , biology , endocrinology , lipoprotein , cholesterol , in vitro , biochemistry

Cardiovascular disease (CVD), the most common morbidity resulting from atherosclerosis, remains a frequent cause of death. Efforts to develop effective therapeutic strategies have focused on vascular inflammation as a critical pathology driving atherosclerosis progression. Nonetheless, molecular mechanisms underlying this activity remain unclear. Here, we ask whether angiopoietin-like protein 2 (Angptl2), a proinflammatory protein, contributes to vascular inflammation that promotes atherosclerosis progression.

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