Absence of Chemokine (C-X-C Motif) Ligand 10 Diminishes Perfusion Recovery After Local Arterial Occlusion in Mice | Zendy

Pleunie van den Borne | Zendy; René Haverslag | Zendy; Maarten M. Brandt | Zendy; Caroline Cheng | Zendy; Henricus J. Duckers | Zendy; Paul H.A. Quax | Zendy; Imo E. Hoefer | Zendy; Gerard Pasterkamp | Zendy; Dominique P.V. de Kleijn | Zendy

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Absence of Chemokine (C-X-C Motif) Ligand 10 Diminishes Perfusion Recovery After Local Arterial Occlusion in Mice

Author(s) -

Pleunie van den Borne,

René Haverslag,

Maarten M. Brandt,

Caroline Cheng,

Henricus J. Duckers,

Paul H.A. Quax,

Imo E. Hoefer,

Gerard Pasterkamp,

Dominique P.V. de Kleijn

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.303050

Subject(s) - perfusion , chemistry , occlusion , ligand (biochemistry) , chemokine , medicine , microbiology and biotechnology , biology , receptor , biochemistry

In arteriogenesis, pre-existing anastomoses undergo enlargement to restore blood flow in ischemic tissues. Chemokine (C-X-C motif) ligand 10 (CXCL10) is secreted after Toll-like receptor activation. Toll-like receptors are involved in arteriogenesis; however, the role of CXCL10 is still unclear. In this study, we investigated the role for CXCL10 in a murine hindlimb ischemia model.

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