Antiangiogenic Therapy Inhibits Venous Thrombus Resolution | Zendy

Colin E. Evans | Zendy; Steven P. Grover | Zendy; Julia Humphries | Zendy; Prakash Saha | Zendy; Anant Patel | Zendy; Ashish Patel | Zendy; Oliver Lyons | Zendy; Matt Waltham | Zendy; Bijan Modarai | Zendy; Alberto Smith | Zendy

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Antiangiogenic Therapy Inhibits Venous Thrombus Resolution

Author(s) -

Colin E. Evans,

Steven P. Grover,

Julia Humphries,

Prakash Saha,

Anant Patel,

Ashish Patel,

Oliver Lyons,

Matt Waltham,

Bijan Modarai,

Alberto Smith

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302998

Subject(s) - thrombus , medicine , axitinib , neovascularization , angiogenesis , cardiology , gastroenterology , surgery , cancer , sunitinib

Venous thromboembolism is a common complication in patients with cancer, resulting in significant morbidity and mortality. Clinical studies suggest that the incidence of venous thromboembolic events increased after treatment of these patients with antiangiogenic agents. Thrombi resolve through a process of remodeling, involving the formation of microvascular channels within the thrombus. Our aim was to determine whether inhibiting angiogenesis affects venous thrombus resolution.

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