Pharmacological Activation of the Melanocortin System Limits Plaque Inflammation and Ameliorates Vascular Dysfunction in Atherosclerotic Mice | Zendy

Petteri Rinne | Zendy; Johanna M. U. Silvola | Zendy; Sanna Hellberg | Zendy; Mia Ståhle | Zendy; Heidi Liljenbäck | Zendy; Henriikka Salomäki | Zendy; Emilia Koskinen | Zendy; Salla Nuutinen | Zendy; Pekka Saukko | Zendy; Juhani Knuuti | Zendy; Antti Saraste | Zendy; Anne Roivainen | Zendy; Eriika Savontaus | Zendy

Open Access

Pharmacological Activation of the Melanocortin System Limits Plaque Inflammation and Ameliorates Vascular Dysfunction in Atherosclerotic Mice

Author(s) -

Petteri Rinne,

Johanna M. U. Silvola,

Sanna Hellberg,

Mia Ståhle,

Heidi Liljenbäck,

Henriikka Salomäki,

Emilia Koskinen,

Salla Nuutinen,

Pekka Saukko,

Juhani Knuuti,

Antti Saraste,

Anne Roivainen,

Eriika Savontaus

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302963

Subject(s) - inflammation , melanocortin , medicine , endothelial dysfunction , vascular disease , endocrinology , pathology , receptor

Melanocortin peptides have been shown to elicit anti-inflammatory actions and to promote vascular endothelial function by activating type 1 and 3 melanocortin receptors. Here, we addressed whether these favorable properties of melanocortins could reduce atherosclerotic plaque inflammation and improve vasoreactivity in atherosclerotic mice.

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