Coenzyme Q10 Promotes Macrophage Cholesterol Efflux by Regulation of the Activator Protein-1/miR-378/ATP-Binding Cassette Transporter G1–Signaling Pathway | Zendy

Dongliang Wang | Zendy; Yan Xiao | Zendy; Min Xia | Zendy; Yan Yang | Zendy; Dan Li | Zendy; Xinrui Li | Zendy; Fenglin Song | Zendy; Wenhua Ling | Zendy

Open Access

Coenzyme Q10 Promotes Macrophage Cholesterol Efflux by Regulation of the Activator Protein-1/miR-378/ATP-Binding Cassette Transporter G1–Signaling Pathway

Author(s) -

Dongliang Wang,

Yan Xiao,

Min Xia,

Yan Yang,

Dan Li,

Xinrui Li,

Fenglin Song,

Wenhua Ling

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302879

Subject(s) - activator (genetics) , atp binding cassette transporter , reverse cholesterol transport , efflux , cholesterol , atp binding cassette transporter 1 , macrophage , transporter , coenzyme q10 , microbiology and biotechnology , apolipoprotein b , lipoprotein , biology , biochemistry , abca1 , chemistry , receptor , in vitro , gene

Recent studies have shown the role of miRNAs in macrophage reverse cholesterol transport and atherogenesis. We hypothesized that coenzyme Q10 (CoQ10) may increase macrophage reverse cholesterol transport by regulating miRNA expression that contributes to the prevention of atherosclerosis.

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