Aldosterone Promotes Vascular Remodeling by Direct Effects on Smooth Muscle Cell Mineralocorticoid Receptors | Zendy

Dafina Pruthi | Zendy; Amy McCurley | Zendy; Mark Aronovitz | Zendy; Carol Galayda | Zendy; S. Ananth Karumanchi | Zendy; Iris Z. Jaffe | Zendy

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Aldosterone Promotes Vascular Remodeling by Direct Effects on Smooth Muscle Cell Mineralocorticoid Receptors

Author(s) -

Dafina Pruthi,

Amy McCurley,

Mark Aronovitz,

Carol Galayda,

S. Ananth Karumanchi,

Iris Z. Jaffe

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302854

Subject(s) - mineralocorticoid receptor , aldosterone , endocrinology , medicine , mineralocorticoid , vascular smooth muscle , receptor , placental growth factor , biology , fibrosis , vascular endothelial growth factor b , vascular endothelial growth factor , vascular endothelial growth factor a , smooth muscle , vegf receptors

Vascular remodeling occurs after endothelial injury, resulting in smooth muscle cell (SMC) proliferation and vascular fibrosis. We previously demonstrated that the blood pressure-regulating hormone aldosterone enhances vascular remodeling in mice at sites of endothelial injury in a placental growth factor-dependent manner. We now test the hypothesis that SMC mineralocorticoid receptors (MRs) directly mediate the remodeling effects of aldosterone and further explore the mechanism.

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