Insulin-Regulated Protein Palmitoylation Impacts Endothelial Cell Function | Zendy

Xiaochao Wei | Zendy; Haowei Song | Zendy; Clay F. Semenkovich | Zendy

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Insulin-Regulated Protein Palmitoylation Impacts Endothelial Cell Function

Author(s) -

Xiaochao Wei,

Haowei Song,

Clay F. Semenkovich

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302848

Subject(s) - palmitoylation , microbiology and biotechnology , biology , insulin , insulin receptor , endothelial stem cell , angiogenesis , gene knockdown , biochemistry , insulin resistance , cysteine , in vitro , endocrinology , cancer research , apoptosis , enzyme

Defects in insulin signaling are associated with abnormal endothelial cell function, which occurs commonly in cardiovascular disease. Targets of insulin signaling in endothelial cells are incompletely understood. Protein S-palmitoylation, the reversible modification of proteins by the lipid palmitate, is a post-translational process relevant to cell signaling, but little is known about the role of insulin in protein palmitoylation.

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