Group VIA Phospholipase A 2 Mediates Enhanced Macrophage Migration in Diabetes Mellitus by Increasing Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 | Zendy

Chunyan Tan | Zendy; Robert T. Day | Zendy; Shunzhong Bao | Zendy; John Turk | Zendy; Qingwei Zhao | Zendy

Open Access

Group VIA Phospholipase A ₂ Mediates Enhanced Macrophage Migration in Diabetes Mellitus by Increasing Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4

Author(s) -

Chunyan Tan,

Robert T. Day,

Shunzhong Bao,

John Turk,

Qingwei Zhao

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302847

Subject(s) - nicotinamide adenine dinucleotide phosphate , lysophosphatidic acid , nox4 , nadph oxidase , endocrinology , medicine , biology , monocyte , oxidase test , receptor , biochemistry , oxidative stress , enzyme

We previously demonstrated that nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) mediates increased monocyte priming and chemotaxis under conditions of diabetic metabolic stress, and emerging data indicate that group VIA phospholipase A2 (iPLA2β) also participates in regulating monocyte chemotaxis. Here, we examined relationships between iPLA2β expression and Nox4 action in mouse peritoneal macrophages subjected to diabetic metabolic stress.

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