Transmembrane Protein 55B Is a Novel Regulator of Cellular Cholesterol Metabolism | Zendy

Marisa W. Medina | Zendy; Frederick Bauzon | Zendy; Devesh Naidoo | Zendy; Elizabeth Theusch | Zendy; Kristen N. Stevens | Zendy; Jessica Schilde | Zendy; Christian Schubert | Zendy; Lara M. Mangravite | Zendy; Lawrence L. Rudel | Zendy; Ryan E. Temel | Zendy; Heiko Runz | Zendy; Ronald M. Krauss | Zendy

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Transmembrane Protein 55B Is a Novel Regulator of Cellular Cholesterol Metabolism

Author(s) -

Marisa W. Medina,

Frederick Bauzon,

Devesh Naidoo,

Elizabeth Theusch,

Kristen N. Stevens,

Jessica Schilde,

Christian Schubert,

Lara M. Mangravite,

Lawrence L. Rudel,

Ryan E. Temel,

Heiko Runz,

Ronald M. Krauss

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302806

Subject(s) - biology , gene knockdown , cholesterol , ldl receptor , lipid metabolism , microbiology and biotechnology , abca1 , cell culture , lipoprotein , endocrinology , biochemistry , gene , genetics , transporter

Interindividual variation in pathways affecting cellular cholesterol metabolism can influence levels of plasma cholesterol, a well-established risk factor for cardiovascular disease. Inherent variation among immortalized lymphoblastoid cell lines from different donors can be leveraged to discover novel genes that modulate cellular cholesterol metabolism. The objective of this study was to identify novel genes that regulate cholesterol metabolism by testing for evidence of correlated gene expression with cellular levels of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) mRNA, a marker for cellular cholesterol homeostasis, in a large panel of lymphoblastoid cell lines.

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