Differential Association of Plasma Angiopoietin-Like Proteins 3 and 4 With Lipid and Metabolic Traits | Zendy

Nidhi Mehta | Zendy; Arman Qamar | Zendy; Liming Qu | Zendy; Atif Qasim | Zendy; Nehal N. Mehta | Zendy; Muredach P. Reilly | Zendy; Daniel J. Rader | Zendy

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Differential Association of Plasma Angiopoietin-Like Proteins 3 and 4 With Lipid and Metabolic Traits

Author(s) -

Nidhi Mehta,

Arman Qamar,

Liming Qu,

Atif Qasim,

Nehal N. Mehta,

Muredach P. Reilly,

Daniel J. Rader

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302802

Subject(s) - angptl4 , medicine , endocrinology , cholesterol , lipoprotein , high density lipoprotein , biology , lipoprotein lipase , metabolic syndrome , diabetes mellitus , biochemistry , gene , adipose tissue

Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) are secreted proteins that inhibit lipoprotein lipase in vitro. Genetic variants at the ANGPTL3 and ANGPTL4 gene loci are significantly associated with plasma lipid traits. The aim of this study was to evaluate the association of plasma ANGPTL3 and ANGPTL4 concentrations with lipid and metabolic traits in a large community-based sample.

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