Lim Domain Binding 2 | Zendy

Ming-Mei Shang | Zendy; Husain A. Talukdar | Zendy; Jennifer J. Hofmann | Zendy; Colin Niaudet | Zendy; Hassan Foroughi Asl | Zendy; Rajeev Jain | Zendy; Aránzazu Rossignoli | Zendy; Cecilia Cedergren | Zendy; Angela Silveira | Zendy; Bruna Gigante | Zendy; Karin Leander | Zendy; Ulf dé Fairé | Zendy; Anders Hamsten | Zendy; Arno Ruusalepp | Zendy; Olle Melander | Zendy; Torbjörn Ivert | Zendy; Tom Michoel | Zendy; Eric E. Schadt | Zendy; Christer Betsholtz | Zendy; Josefin Skogsberg | Zendy; Johan Björkegren | Zendy

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Lim Domain Binding 2

Author(s) -

Ming-Mei Shang,

Husain A. Talukdar,

Jennifer J. Hofmann,

Colin Niaudet,

Hassan Foroughi Asl,

Rajeev Jain,

Aránzazu Rossignoli,

Cecilia Cedergren,

Angela Silveira,

Bruna Gigante,

Karin Leander,

Ulf dé Fairé,

Anders Hamsten,

Arno Ruusalepp,

Olle Melander,

Torbjörn Ivert,

Tom Michoel,

Eric E. Schadt,

Christer Betsholtz,

Josefin Skogsberg,

Johan Björkegren

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302709

Subject(s) - domain (mathematical analysis) , computational biology , biology , microbiology and biotechnology , mathematics , mathematical analysis

Using a multi-tissue, genome-wide gene expression approach, we recently identified a gene module linked to the extent of human atherosclerosis. This atherosclerosis module was enriched with inherited risk for coronary and carotid artery disease (CAD) and overlapped with genes in the transendothelial migration of leukocyte (TEML) pathway. Among the atherosclerosis module genes, the transcription cofactor Lim domain binding 2 (LDB2) was the most connected in a CAD vascular wall regulatory gene network. Here, we used human genomics and atherosclerosis-prone mice to evaluate the possible role of LDB2 in TEML and atherosclerosis.

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