G-Protein–Coupled Receptor-2–Interacting Protein-1 Is Required for Endothelial Cell Directional Migration and Tumor Angiogenesis via Cortactin-Dependent Lamellipodia Formation | Zendy

Syamantak Majumder | Zendy; Mark P. Sowden | Zendy; Scott A. Gerber | Zendy; Tamlyn Thomas | Zendy; Christine K. Christie | Zendy; Amy Mohan | Zendy; Guoyong Yin | Zendy; Edith M. Lord | Zendy; Bradford C. Berk | Zendy; Jinjiang Pang | Zendy

Open Access

G-Protein–Coupled Receptor-2–Interacting Protein-1 Is Required for Endothelial Cell Directional Migration and Tumor Angiogenesis via Cortactin-Dependent Lamellipodia Formation

Author(s) -

Syamantak Majumder,

Mark P. Sowden,

Scott A. Gerber,

Tamlyn Thomas,

Christine K. Christie,

Amy Mohan,

Guoyong Yin,

Edith M. Lord,

Bradford C. Berk,

Jinjiang Pang

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302689

Subject(s) - lamellipodium , cortactin , angiogenesis , cell migration , microbiology and biotechnology , receptor , cancer research , endothelial stem cell , chemistry , biology , cell , cytoskeleton , biochemistry , in vitro

Recent evidence suggests G-protein-coupled receptor-2-interacting protein-1 (GIT1) overexpression in several human metastatic tumors, including breast, lung, and prostate. Tumor metastasis is associated with an increase in angiogenesis. We have showed previously that GIT1 is required for postnatal angiogenesis during lung development. However, the functional role of GIT1 in pathological angiogenesis during tumor growth is unknown.

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