Clinical-Grade Human Neural Stem Cells Promote Reparative Neovascularization in Mouse Models of Hindlimb Ischemia | Zendy

Rajesh Katare | Zendy; Paul Stroemer | Zendy; Caroline Hicks | Zendy; Lara Stevanato | Zendy; Sara Patel | Zendy; Randolph Corteling | Zendy; Erik Miljan | Zendy; Indira Vishnubhatla | Zendy; John D. Sinden | Zendy; Paolo Madeddu | Zendy

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Clinical-Grade Human Neural Stem Cells Promote Reparative Neovascularization in Mouse Models of Hindlimb Ischemia

Author(s) -

Rajesh Katare,

Paul Stroemer,

Caroline Hicks,

Lara Stevanato,

Sara Patel,

Randolph Corteling,

Erik Miljan,

Indira Vishnubhatla,

John D. Sinden,

Paolo Madeddu

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302592

Subject(s) - hindlimb , ischemia , medicine , neovascularization , angiogenesis , blood flow , neurogenesis , perfusion , infarction , neural stem cell , anesthesia , pathology , stem cell , biology , neuroscience , myocardial infarction , genetics

CTX0E03 (CTX) is a clinical-grade human neural stem cell (hNSC) line that promotes angiogenesis and neurogenesis in a preclinical model of stroke and is now under clinical development for stroke disability. We evaluated the therapeutic activity of intramuscular CTX hNSC implantation in murine models of hindlimb ischemia for potential translation to clinical studies in critical limb ischemia.

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