Genetic Reduction of Vascular Endothelial Growth Factor Receptor 2 Rescues Aberrant Angiogenesis Caused by Epsin Deficiency | Zendy

Kandice L. Tessneer | Zendy; Satish Pasula | Zendy; Xiaofeng Cai | Zendy; Yunzhou Dong | Zendy; John McManus | Zendy; Xiaolei Liu | Zendy; Lili Yu | Zendy; Scott Hahn | Zendy; Baojun Chang | Zendy; Yiyuan Chen | Zendy; Courtney T. Griffin | Zendy; Lijun Xia | Zendy; Ralf H. Adams | Zendy; Hong Chen | Zendy

Open Access

Genetic Reduction of Vascular Endothelial Growth Factor Receptor 2 Rescues Aberrant Angiogenesis Caused by Epsin Deficiency

Author(s) -

Kandice L. Tessneer,

Satish Pasula,

Xiaofeng Cai,

Yunzhou Dong,

John McManus,

Xiaolei Liu,

Lili Yu,

Scott Hahn,

Baojun Chang,

Yiyuan Chen,

Courtney T. Griffin,

Lijun Xia,

Ralf H. Adams,

Hong Chen

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302586

Subject(s) - angiogenesis , biology , kinase insert domain receptor , downregulation and upregulation , vascular endothelial growth factor , microbiology and biotechnology , angiogenesis inhibitor , endothelial stem cell , embryonic stem cell , cancer research , vascular endothelial growth factor a , vegf receptors , in vitro , genetics , gene

We previously showed that endothelial epsin deficiency caused elevated vascular endothelial growth factor receptor 2 (VEGFR2) and enhanced VEGF signaling, resulting in aberrant tumor angiogenesis and reduced tumor growth in adult mice. However, direct evidence demonstrating that endothelial epsins regulate angiogenesis specifically through VEGFR2 downregulation is still lacking. In addition, whether the lack of epsins causes abnormal angiogenesis during embryonic development remains unclear.

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