Cystathionine γ-lyase Accelerates Osteoclast Differentiation | Zendy

Takahiro Ito | Zendy; Natalia Maldonado | Zendy; Iwao Yamada | Zendy; Claudia Goettsch | Zendy; Jiro Matsumoto | Zendy; Masanori Aikawa | Zendy; Sasha A. Singh | Zendy; Elena Aïkawa | Zendy

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Cystathionine γ-lyase Accelerates Osteoclast Differentiation

Author(s) -

Takahiro Ito,

Natalia Maldonado,

Iwao Yamada,

Claudia Goettsch,

Jiro Matsumoto,

Masanori Aikawa,

Sasha A. Singh,

Elena Aïkawa

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302576

Subject(s) - osteoclast , rank ligand , rankl , activator (genetics) , bone resorption , microbiology and biotechnology , gene knockdown , biology , gene silencing , cellular differentiation , chemistry , receptor , biochemistry , endocrinology , gene

Clinical evidence has linked vascular calcification in advanced atherosclerotic plaques with overt cardiovascular disease and mortality. Bone resorbing monocyte-derived osteoclast-like cells are sparse in these plaques, indicating that their differentiation capability could be suppressed. Here, we seek to characterize the process of osteoclastogenesis by identifying novel regulators and pathways, with the aim of exploring possible strategies to reduce calcification.

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