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Myeloperoxidase-enriched monocytes play important roles in inflammatory disease, such as atherosclerosis. We previously demonstrated that α-chlorofatty aldehydes are produced as a result of plasmalogen targeting by myeloperoxidase-derived hypochlorous acid in activated monocytes. Here, we show α-chlorofatty acid (α-ClFA), a stable metabolite of α-chlorofatty aldehydes, accumulates in activated monocytes and mediates the molecular effects of α-ClFA on monocytes/macrophages.

arteriosclerosis, thrombosis, and vascular biology

Alpha-Chlorofatty Acid Accumulates in Activated Monocytes and Causes Apoptosis Through Reactive Oxygen Species Production and Endoplasmic Reticulum Stress