Multiple-Site Activation of the Cysteinyl Leukotriene Receptor 2 Is Required for Exacerbation of Ischemia/Reperfusion Injury | Zendy

Nathan C. Ni | Zendy; Laurel L. Ballantyne | Zendy; Jeffrey Mewburn | Zendy; Colin Funk | Zendy

Open Access

Multiple-Site Activation of the Cysteinyl Leukotriene Receptor 2 Is Required for Exacerbation of Ischemia/Reperfusion Injury

Author(s) -

Nathan C. Ni,

Laurel L. Ballantyne,

Jeffrey Mewburn,

Colin Funk

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302536

Subject(s) - vascular permeability , receptor , genetically modified mouse , inflammation , transgene , endothelium , biology , endogeny , stimulation , ischemia , knockout mouse , chemistry , microbiology and biotechnology , immunology , medicine , endocrinology , biochemistry , gene

Transgenic overexpression of the human cysteinyl leukotriene receptor 2 (CysLT2R) in murine endothelium exacerbates vascular permeability and ischemia/reperfusion injury. Here, we explore the underlying mechanisms of CysLT2R activation-mediated inflammation and delineate the relative contributions of endogenous murine CysLT2R and the transgene-derived receptor.

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