Cyclic Adenosine Monophosphate-Response Element–Binding Protein Mediates the Proangiogenic or Proinflammatory Activity of Gremlin | Zendy

Michela Corsini | Zendy; Emanuela Moroni | Zendy; Cosetta Ravelli | Zendy; Germán Andrés | Zendy; Elisabetta Grillo | Zendy; Imran Ali | Zendy; Derek P. Brazil | Zendy; Marco Presta | Zendy; Stefania Mitola | Zendy

Open Access

Cyclic Adenosine Monophosphate-Response Element–Binding Protein Mediates the Proangiogenic or Proinflammatory Activity of Gremlin

Author(s) -

Michela Corsini,

Emanuela Moroni,

Cosetta Ravelli,

Germán Andrés,

Elisabetta Grillo,

Imran Ali,

Derek P. Brazil,

Marco Presta,

Stefania Mitola

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302517

Subject(s) - proinflammatory cytokine , creb , microbiology and biotechnology , cyclic amp response element binding protein , angiogenesis , chemokine , chemistry , biology , cancer research , inflammation , receptor , transcription factor , immunology , biochemistry , gene

Angiogenesis and inflammation are closely related processes. Gremlin is a novel noncanonical vascular endothelial growth factor receptor-2 (VEGFR2) ligand that induces a proangiogenic response in endothelial cells (ECs). Here, we investigated the role of the cyclic adenosine monophosphate-response element (CRE)-binding protein (CREB) in mediating the proinflammatory and proangiogenic responses of ECs to gremlin.

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