Hedgehog-Dependent Regulation of Angiogenesis and Myogenesis Is Impaired in Aged Mice
Author(s) -
MarieAnge Renault,
Fanny Robbesyn,
Candice Chapouly,
Qinyu Yao,
Soizic Vandierdonck,
Annabel Reynaud,
Isabelle Belloc,
Élisabeth Traiffort,
Martial Ruat,
Claude Des̀granges,
AlainPierre Gadeau
Publication year - 2013
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.113.302494
Subject(s) - smoothened , myogenesis , downregulation and upregulation , angiogenesis , gli1 , endocrinology , sonic hedgehog , hedgehog signaling pathway , medicine , hedgehog , biology , skeletal muscle , signal transduction , microbiology and biotechnology , genetics , gene
The purpose of this study is to further document alteration of signal transduction pathways, more particularly of hedgehog (Hh) signaling, causing impaired ischemic muscle repair in old mice.
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