HIV-1 Matrix Protein p17 Promotes Lymphangiogenesis and Activates the Endothelin-1/Endothelin B Receptor Axis | Zendy

Francesca Caccuri | Zendy; Christine Rueckert | Zendy; Cinzia Giagulli | Zendy; Kai Schulze | Zendy; Daniele Basta | Zendy; Sonia Zicari | Zendy; Stefania Marsico | Zendy; Edoardo Cervi | Zendy; Simona Fiorentini | Zendy; Mark Slevin | Zendy; Carlos A. Guzmán | Zendy; Arnaldo Caruso | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

HIV-1 Matrix Protein p17 Promotes Lymphangiogenesis and Activates the Endothelin-1/Endothelin B Receptor Axis

Author(s) -

Francesca Caccuri,

Christine Rueckert,

Cinzia Giagulli,

Kai Schulze,

Daniele Basta,

Sonia Zicari,

Stefania Marsico,

Edoardo Cervi,

Simona Fiorentini,

Mark Slevin,

Carlos A. Guzmán,

Arnaldo Caruso

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302478

Subject(s) - lymphangiogenesis , lymphatic system , lymphatic endothelium , cancer research , chemokine receptor , biology , lymphatic vessel , endothelin 3 , lymph node , microbiology and biotechnology , matrigel , lymph node stromal cell , protein kinase b , chemokine , receptor , signal transduction , endothelin receptor , immunology , medicine , angiogenesis , inflammation , endothelins , metastasis , cancer , biochemistry

AIDS-related lymphomas are high grade and aggressively metastatic with poor prognosis. Lymphangiogenesis is essential in supporting proliferation and survival of lymphoma, as well as tumor dissemination. Data suggest that aberrant lymphangiogenesis relies on action of HIV-1 proteins rather than on a direct effect of the virus itself. HIV-1 matrix protein p17 was found to accumulate and persist in lymph nodes of patients even under highly active antiretroviral therapy. Because p17 was recently found to exert a potent proangiogenic activity by interacting with chemokine (C-X-C motif) receptors 1 and 2, we tested the prolymphangiogenic activity of the viral protein.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research