Apoptosis Signal–Regulating Kinase 1 Is a Novel Target Molecule for Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion | Zendy

Kensuke Toyama | Zendy; Nobutaka Koibuchi | Zendy; Ken Uekawa | Zendy; Yu Hasegawa | Zendy; Keiichiro Kataoka | Zendy; Tetsuji Katayama | Zendy; Daisuke Sueta | Zendy; Jie Ming | Zendy; Takashi Nakagawa | Zendy; Osamu Yasuda | Zendy; Hidekazu Tomimoto | Zendy; Hidenori Ichijo | Zendy; Hisao Ogawa | Zendy; Shokei KimMitsuyama | Zendy

Open Access

Apoptosis Signal–Regulating Kinase 1 Is a Novel Target Molecule for Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion

Author(s) -

Kensuke Toyama,

Nobutaka Koibuchi,

Ken Uekawa,

Yu Hasegawa,

Keiichiro Kataoka,

Tetsuji Katayama,

Daisuke Sueta,

Jie Ming,

Takashi Nakagawa,

Osamu Yasuda,

Hidekazu Tomimoto,

Hidenori Ichijo,

Hisao Ogawa,

Shokei KimMitsuyama

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302440

Subject(s) - white matter , cognitive decline , ask1 , endocrinology , biology , medicine , pathology , protein kinase a , dementia , kinase , microbiology and biotechnology , magnetic resonance imaging , disease , mitogen activated protein kinase kinase , radiology

There are currently no specific strategies for the treatment or prevention of vascular dementia. White matter lesions, a common pathology in cerebral small vessel disease, are a major cause of vascular dementia. We investigated whether apoptosis signal-regulating kinase 1 (ASK1) might be a key molecule in cerebral hypoperfusion, associated with blood-brain barrier breakdown and white matter lesions.

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