Plasma S100A8/A9 Correlates With Blood Neutrophil Counts, Traditional Risk Factors, and Cardiovascular Disease in Middle-Aged Healthy Individuals | Zendy

Ovidiu Simion Cotoi | Zendy; Pontus Dunér | Zendy; Nayoung Ko | Zendy; Bo Hedblad | Zendy; Jan Nilsson | Zendy; Harry Björkbacka | Zendy; Alexandru Șchiopu | Zendy

Open Access

Plasma S100A8/A9 Correlates With Blood Neutrophil Counts, Traditional Risk Factors, and Cardiovascular Disease in Middle-Aged Healthy Individuals

Author(s) -

Ovidiu Simion Cotoi,

Pontus Dunér,

Nayoung Ko,

Bo Hedblad,

Jan Nilsson,

Harry Björkbacka,

Alexandru Șchiopu

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302432

Subject(s) - medicine , s100a8 , neutrophil extracellular traps , hazard ratio , incidence (geometry) , body mass index , population , coronary artery disease , cohort , immunology , gastroenterology , absolute neutrophil count , confidence interval , inflammation , toxicity , neutropenia , physics , environmental health , optics

The S100 alarmins A8, A9, and A8/A9, secreted by activated neutrophils and monocytes/macrophages, are involved in the pathogenesis of various inflammatory diseases. S100A8/A9 has previously been linked to atherogenesis and cardiovascular (CV) disease. We investigated whether S100A8, A9, and A8/A9 correlate with carotid artery disease and CV risk in apparently healthy individuals.

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