Deletion of Cysteine-Cysteine Receptor 7 Promotes Fibrotic Injury in Experimental Post-Thrombotic Vein Wall Remodeling | Zendy

Adriana Laser | Zendy; Megan Elfline | Zendy; Cathy Luke | Zendy; Dallas Slack | Zendy; Anuj Shah | Zendy; Vikram Sood | Zendy; Barry Deatrick | Zendy; Brendan McEvoy | Zendy; Carson Ostra | Zendy; Anthony J. Comerota | Zendy; Steven L. Kunkel | Zendy; Cory M. Hogaboam | Zendy; Peter K. Henke | Zendy

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Deletion of Cysteine-Cysteine Receptor 7 Promotes Fibrotic Injury in Experimental Post-Thrombotic Vein Wall Remodeling

Author(s) -

Adriana Laser,

Megan Elfline,

Cathy Luke,

Dallas Slack,

Anuj Shah,

Vikram Sood,

Barry Deatrick,

Brendan McEvoy,

Carson Ostra,

Anthony J. Comerota,

Steven L. Kunkel,

Cory M. Hogaboam,

Peter K. Henke

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302428

Subject(s) - c c chemokine receptor type 7 , fibrosis , thrombus , medicine , von willebrand factor , pathology , receptor , immunology , platelet , chemokine , chemokine receptor

Deep vein thrombosis (VT) can result in vein wall injury, which clinically manifests as post-thrombotic syndrome. Postinjury fibrosis may be modulated in part through cellular cysteine-cysteine receptor 7 (CCR7)-mediated events. We tested the hypothesis that late vein wall fibrotic remodeling is dependent on CCR7.

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