Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice | Zendy

Christine Koulis | Zendy; YungChih Chen | Zendy; Christian Hausding | Zendy; Ingo Ahrens | Zendy; Tin Kyaw | Zendy; Christopher Tay | Zendy; Terri J. Allen | Zendy; Karin JandeleitDahm | Zendy; Matthew J. Sweet | Zendy; Shizuo Akira | Zendy; A. Bobik | Zendy; Karlheinz Peter | Zendy; Alex Agrotis | Zendy

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Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

Author(s) -

Christine Koulis,

YungChih Chen,

Christian Hausding,

Ingo Ahrens,

Tin Kyaw,

Christopher Tay,

Terri J. Allen,

Karin JandeleitDahm,

Matthew J. Sweet,

Shizuo Akira,

A. Bobik,

Karlheinz Peter,

Alex Agrotis

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302407

Subject(s) - tlr9 , apolipoprotein e , lipoprotein , apolipoprotein b , innate immune system , medicine , endocrinology , immune system , lesion , ldl receptor , inflammation , cholesterol , receptor , biology , immunology , biochemistry , pathology , gene expression , disease , gene , dna methylation

Atherosclerosis is driven by inflammatory reactions that are shared with the innate immune system. Toll-like receptor-9 (TLR9) is an intracellular pattern recognition receptor of the innate immune system that is currently under clinical investigation as a therapeutic target in inflammatory diseases. Here, we investigated whether TLR9 has a role in the development of atherosclerosis in apolipoprotein E-deficient (ApoE(-/-)) mice.

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