Acceleration of Biliary Cholesterol Secretion Restores Glycemic Control and Alleviates Hypertriglyceridemia in Obese db / db Mice | Zendy

Kai Su | Zendy; Nadezhda Sabeva | Zendy; Yuhuan Wang | Zendy; Xiaoxi Liu | Zendy; Joshua Lester | Zendy; Jingjing Liu | Zendy; Shuang Liang | Zendy; Gregory A. Graf | Zendy

Open Access

Acceleration of Biliary Cholesterol Secretion Restores Glycemic Control and Alleviates Hypertriglyceridemia in Obese db / db Mice

Author(s) -

Kai Su,

Nadezhda Sabeva,

Yuhuan Wang,

Xiaoxi Liu,

Joshua Lester,

Jingjing Liu,

Shuang Liang,

Gregory A. Graf

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302355

Subject(s) - medicine , endocrinology , insulin resistance , cholesterol , nonalcoholic fatty liver disease , steatosis , hypertriglyceridemia , insulin , biology , fatty liver , glycemic , triglyceride , disease

Recent studies support a role for cholesterol in the development of obesity and nonalcoholic fatty liver disease. Mice lacking the ABCG5 ABCG8 (G5G8) sterol transporter have reduced biliary cholesterol secretion and are more susceptible to steatosis, hepatic insulin resistance, and loss of glycemic control when challenged with a high-fat diet. We hypothesized that accelerating G5G8-mediated biliary cholesterol secretion would correct these phenotypes in obese mice.

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