Mice With Targeted Inactivation of Ppap2b in Endothelial and Hematopoietic Cells Display Enhanced Vascular Inflammation and Permeability | Zendy

Manikandan Panchatcharam | Zendy; Abdel Salous | Zendy; J. Anthony Brandon | Zendy; Sumitra Miriyala | Zendy; Jessica Wheeler | Zendy; Pooja Patil | Zendy; Manjula Sunkara | Zendy; Andrew J. Morris | Zendy; Diana EscalanteAlcalde | Zendy; Susan S. Smyth | Zendy

Open Access

Mice With Targeted Inactivation of Ppap2b in Endothelial and Hematopoietic Cells Display Enhanced Vascular Inflammation and Permeability

Author(s) -

Manikandan Panchatcharam,

Abdel Salous,

J. Anthony Brandon,

Sumitra Miriyala,

Jessica Wheeler,

Pooja Patil,

Manjula Sunkara,

Andrew J. Morris,

Diana EscalanteAlcalde,

Susan S. Smyth

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302335

Subject(s) - lysophosphatidic acid , autotaxin , inflammation , vascular permeability , biology , microbiology and biotechnology , cancer research , immunology , receptor , endocrinology , biochemistry

Lipid phosphate phosphatase 3 (LPP3), encoded by the PPAP2B gene, is an integral membrane enzyme that dephosphorylates, and thereby terminates, the G-protein-coupled receptor-mediated signaling actions of lysophosphatidic acid (LPA) and sphingosine-1-phosphate. LPP3 is essential for normal vascular development in mice, and a common PPAP2B polymorphism is associated with increased risk of coronary artery disease in humans. Herein, we investigate the function of endothelial LPP3 to understand its role in the development and human disease.

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