Hypoxia Induces Metalloproteinase-9 Activation and Human Vascular Smooth Muscle Cell Migration Through Low-Density Lipoprotein Receptor–Related Protein 1–Mediated Pyk2 Phosphorylation | Zendy

Elena RevueltaLópez | Zendy; José Castellano | Zendy; Santiago Roura | Zendy; Carolina GálvezMontón | Zendy; Laura Nasarre | Zendy; Sònia Benı́tez | Zendy; Antoni BayésGenís | Zendy; Lina Badimón | Zendy; Vicenta LlorenteCortés | Zendy

Open Access

Hypoxia Induces Metalloproteinase-9 Activation and Human Vascular Smooth Muscle Cell Migration Through Low-Density Lipoprotein Receptor–Related Protein 1–Mediated Pyk2 Phosphorylation

Author(s) -

Elena RevueltaLópez,

José Castellano,

Santiago Roura,

Carolina GálvezMontón,

Laura Nasarre,

Sònia Benı́tez,

Antoni BayésGenís,

Lina Badimón,

Vicenta LlorenteCortés

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302323

Subject(s) - hypoxia (environmental) , vascular smooth muscle , microbiology and biotechnology , phosphorylation , chemistry , receptor , ldl receptor , smooth muscle , low density lipoprotein , cell migration , endocrinology , medicine , lipoprotein , cell , biochemistry , biology , cholesterol , oxygen , organic chemistry

Hypoxia disturbs vascular function by promoting extracellular matrix remodeling. Extracellular matrix integrity and composition are modulated by metalloproteinases (MMPs). Our aim was to investigate the role of low-density lipoprotein receptor-related protein 1 (LRP1) in regulating MMP-9/MMP-2 activation and vascular smooth muscle cells (VSMCs) migration in response to hypoxia, and to elucidate the LRP1-signaling pathways involved in this process.

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