p21-Dependent Protective Effects of a Carbon Monoxide–Releasing Molecule-3 in Pulmonary Hypertension | Zendy

Shariq Abid | Zendy; Amal Houssaïni | Zendy; Nathalie Mouraret | Zendy; Élisabeth Marcos | Zendy; Valérie Amsellem | Zendy; Feng Wan | Zendy; Jean Luc Dubois-Randé | Zendy; Geneviève Dérumeaux | Zendy; Jorge Boczkowski | Zendy; Roberto Motterlini | Zendy; Serge Adnot | Zendy

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p21-Dependent Protective Effects of a Carbon Monoxide–Releasing Molecule-3 in Pulmonary Hypertension

Author(s) -

Shariq Abid,

Amal Houssaïni,

Nathalie Mouraret,

Élisabeth Marcos,

Valérie Amsellem,

Feng Wan,

Jean Luc Dubois-Randé,

Geneviève Dérumeaux,

Jorge Boczkowski,

Roberto Motterlini,

Serge Adnot

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302302

Subject(s) - hypoxia (environmental) , inhalation , pulmonary hypertension , lung , corm , chemistry , endocrinology , pulmonary artery , medicine , pharmacology , biology , anesthesia , oxygen , organic chemistry , agronomy

Carbon monoxide-releasing molecules (CORMs) represent a pharmacological alternative to CO gas inhalation. Here, we questioned whether CORM-3, a well-characterized water-soluble CORM, could prevent and reverse pulmonary hypertension (PH) in chronically hypoxic mice and in smooth muscle promoter 22 serotonin transporter mice overexpressing the serotonin transporter in smooth muscle cells (SMCs).

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