N ε -(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and Insulin Resistance | Zendy

Katrien H.J. Gaens | Zendy; Gijs H. Goossens | Zendy; Petra Niessen | Zendy; Marleen M. J. van Greevenbroek | Zendy; Carla Kallen | Zendy; Hans W.M. Niessen | Zendy; Sander S. Rensen | Zendy; Wim A. Buurman | Zendy; Jan Greve | Zendy; Ellen E. Blaak | Zendy; Marc A. van Zandvoort | Zendy; Angelika Bierhaus | Zendy; Coen D.A. Stehouwer | Zendy; Casper G. Schalkwijk | Zendy

Open Access

N ^ε -(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and Insulin Resistance

Author(s) -

Katrien H.J. Gaens,

Gijs H. Goossens,

Petra Niessen,

Marleen M. J. van Greevenbroek,

Carla Kallen,

Hans W.M. Niessen,

Sander S. Rensen,

Wim A. Buurman,

Jan Greve,

Ellen E. Blaak,

Marc A. van Zandvoort,

Angelika Bierhaus,

Coen D.A. Stehouwer,

Casper G. Schalkwijk

Publication year - 2014

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302281

Subject(s) - adipokine , insulin resistance , glycation , advanced glycation end product , lysine , endocrinology , medicine , receptor , chemistry , insulin , obesity , insulin receptor , microbiology and biotechnology , biology , biochemistry , amino acid

Dysregulation of inflammatory adipokines by the adipose tissue plays an important role in obesity-associated insulin resistance. Pathways leading to this dysregulation remain largely unknown. We hypothesized that the receptor for advanced glycation end products (RAGE) and the ligand N(ε)-(carboxymethyl)lysine (CML) are increased in adipose tissue and, moreover, that activation of the CML-RAGE axis plays an important role in obesity-associated inflammation and insulin resistance.

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