Deficiency of Endogenous Acute Phase Serum Amyloid A Does Not Affect Atherosclerotic Lesions in Apolipoprotein E–Deficient Mice | Zendy

Maria C. de Beer | Zendy; Joanne M. Wroblewski | Zendy; Victoria P. Noffsinger | Zendy; Debra L. Rateri | Zendy; Deborah A. Howatt | Zendy; Anju Balakrishnan | Zendy; Ailing Ji | Zendy; Preetha Shridas | Zendy; Joel Thompson | Zendy; Deneys R. van der Westhuyzen | Zendy; Lisa R. Tannock | Zendy; Alan Daugherty | Zendy; Nancy R. Webb | Zendy; Frederick C. de Beer | Zendy

Open Access

Deficiency of Endogenous Acute Phase Serum Amyloid A Does Not Affect Atherosclerotic Lesions in Apolipoprotein E–Deficient Mice

Author(s) -

Maria C. de Beer,

Joanne M. Wroblewski,

Victoria P. Noffsinger,

Debra L. Rateri,

Deborah A. Howatt,

Anju Balakrishnan,

Ailing Ji,

Preetha Shridas,

Joel Thompson,

Deneys R. van der Westhuyzen,

Lisa R. Tannock,

Alan Daugherty,

Nancy R. Webb,

Frederick C. de Beer

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302247

Subject(s) - endogeny , affect (linguistics) , serum amyloid a , apolipoprotein e , serum amyloid p component , apolipoprotein b , medicine , amyloid (mycology) , acute phase protein , endocrinology , pathology , psychology , c reactive protein , inflammation , cholesterol , disease , communication

Although elevated plasma concentrations of serum amyloid A (SAA) are associated strongly with increased risk for atherosclerotic cardiovascular disease in humans, the role of SAA in the pathogenesis of lesion formation remains obscure. Our goal was to determine the impact of SAA deficiency on atherosclerosis in hypercholesterolemic mice.

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