Modulation of Protein C Activation by Histones, Platelet Factor 4, and Heparinoids | Zendy

M. Anna Kowalska | Zendy; Guohua Zhao | Zendy; Li Zhai | Zendy; George David | Zendy; Stephen Marcus | Zendy; Sriram Krishnaswamy | Zendy; Mortimer Poncz | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Modulation of Protein C Activation by Histones, Platelet Factor 4, and Heparinoids

Author(s) -

M. Anna Kowalska,

Guohua Zhao,

Li Zhai,

George David,

Stephen Marcus,

Sriram Krishnaswamy,

Mortimer Poncz

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302236

Subject(s) - heparin , heparinoid , tissue factor , partial thromboplastin time , protein c , histone , platelet , thrombomodulin , chemistry , platelet activation , in vitro , thromboplastin , thrombin , pharmacology , immunology , medicine , coagulation , microbiology and biotechnology , biochemistry , biology , gene

Histones are detrimental in late sepsis. Both activated protein C (aPC) and heparin can reverse their effect. Here, we investigated whether histones can modulate aPC generation in a manner similar to another positively charged molecule, platelet factor 4, and how heparinoids (unfractionated heparin or oxygen-desulfated unfractionated heparin with marked decrease anticoagulant activity) may modulate this effect.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research