Expansion of the NKG2C+ Natural Killer–Cell Subset Is Associated With High-Risk Carotid Atherosclerotic Plaques in Seropositive Patients for Human Cytomegalovirus | Zendy

José Rodríguez | Zendy; Jessica MunnéCollado | Zendy; Raquel Rasal | Zendy; Elisa Cuadrado | Zendy; Luis Roig | Zendy; Ángel Ois | Zendy; Aura Muntasell | Zendy; Teresa Baró | Zendy; Francesc Alameda | Zendy; Jaume Roquer | Zendy; Miguel LópezBotet | Zendy

Open Access

Expansion of the NKG2C+ Natural Killer–Cell Subset Is Associated With High-Risk Carotid Atherosclerotic Plaques in Seropositive Patients for Human Cytomegalovirus

Author(s) -

José Rodríguez,

Jessica MunnéCollado,

Raquel Rasal,

Elisa Cuadrado,

Luis Roig,

Ángel Ois,

Aura Muntasell,

Teresa Baró,

Francesc Alameda,

Jaume Roquer,

Miguel LópezBotet

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302163

Subject(s) - human cytomegalovirus , cytomegalovirus , virology , medicine , immunology , virus , viral disease , herpesviridae

Human cytomegalovirus (HCMV), a pathogen involved in the development and progression of atherosclerosis, promotes in some individuals a marked reconfiguration of the natural killer (NK)-cell compartment whose hallmark is a persistent expansion of a peripheral blood NK-cell subset expressing the CD94/NKG2C NK receptor. We aimed to evaluate whether the HCMV-associated NK-cell compartment reconfiguration is related to carotid atherosclerotic plaque (CAP) instability.

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