Targeted Gene Sequencing Identifies Variants in the Protein C and Endothelial Protein C Receptor Genes in Patients With Unprovoked Venous Thromboembolism | Zendy

Cynthia Wu | Zendy; Dhruva J. Dwivedi | Zendy; Laura Pepler | Zendy; Zakhar Lysov | Zendy; John S. Waye | Zendy; Jim A. Julian | Zendy; Karl C. Desch | Zendy; David Ginsburg | Zendy; Jeffrey I. Weitz | Zendy; Clive Kearon | Zendy; Patricia C. Liaw | Zendy

Open Access

Targeted Gene Sequencing Identifies Variants in the Protein C and Endothelial Protein C Receptor Genes in Patients With Unprovoked Venous Thromboembolism

Author(s) -

Cynthia Wu,

Dhruva J. Dwivedi,

Laura Pepler,

Zakhar Lysov,

John S. Waye,

Jim A. Julian,

Karl C. Desch,

David Ginsburg,

Jeffrey I. Weitz,

Clive Kearon,

Patricia C. Liaw

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302137

Subject(s) - endothelial protein c receptor , exon , gene , nonsynonymous substitution , biology , haplotype , protein c , microbiology and biotechnology , genetics , immunology , genotype , genome , thrombin , biochemistry , platelet

The interaction of protein C (PC) with the endothelial PC receptor (EPCR) enhances activated PC generation. We performed targeted gene sequencing of the PC gene (PROC) and EPCR genes (PROCR) in patients with unprovoked venous thromboembolism (VTE) to determine whether mutations that impair PC-EPCR interactions are associated with an increased risk of VTE.

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