Deficiency of NOX1/Nicotinamide Adenine Dinucleotide Phosphate, Reduced Form Oxidase Leads to Pulmonary Vascular Remodeling | Zendy

K Iwata | Zendy; Kanako Ikami | Zendy; Kuniharu Matsuno | Zendy; Toshiharu Yamashita | Zendy; Dai Shiba | Zendy; Masakazu Ibi | Zendy; Misaki Matsumoto | Zendy; Masato Katsuyama | Zendy; Wenhao Cui | Zendy; Jia Zhang | Zendy; Kai Zhu | Zendy; Norio Takei | Zendy; Yasuo Kokai | Zendy; Osamu Ohneda | Zendy; Takahiko Yokoyama | Zendy; Chihiro YabeNishimura | Zendy

Open Access

Deficiency of NOX1/Nicotinamide Adenine Dinucleotide Phosphate, Reduced Form Oxidase Leads to Pulmonary Vascular Remodeling

Author(s) -

K Iwata,

Kanako Ikami,

Kuniharu Matsuno,

Toshiharu Yamashita,

Dai Shiba,

Masakazu Ibi,

Misaki Matsumoto,

Masato Katsuyama,

Wenhao Cui,

Jia Zhang,

Kai Zhu,

Norio Takei,

Yasuo Kokai,

Osamu Ohneda,

Takahiko Yokoyama,

Chihiro YabeNishimura

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302107

Subject(s) - nox1 , nicotinamide adenine dinucleotide phosphate , nadph oxidase , biology , microbiology and biotechnology , endocrinology , medicine , chemistry , oxidase test , oxidative stress , biochemistry , enzyme

Involvement of reactive oxygen species derived from nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase has been documented in the development of hypoxia-induced model of pulmonary arterial hypertension (PAH). Because the PAH-like phenotype was demonstrated in mice deficient in Nox1 gene (Nox1(-/Y)) raised under normoxia, the aim of this study was to clarify how the lack of NOX1/NADPH oxidase could lead to pulmonary pathology.

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