Saturated Fatty Acid Palmitate Aggravates Neointima Formation by Promoting Smooth Muscle Phenotypic Modulation | Zendy

Hua Shen | Zendy; Kosei Eguchi | Zendy; Nozomu Kono | Zendy; Katsuhito Fujiu | Zendy; Sahohime Matsumoto | Zendy; Munehiko Shibata | Zendy; Yumiko Tanaka | Zendy; Issei Komuro | Zendy; Hiroyuki Arai | Zendy; Ryozo Nagai | Zendy; Ichiro Manabe | Zendy

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Saturated Fatty Acid Palmitate Aggravates Neointima Formation by Promoting Smooth Muscle Phenotypic Modulation

Author(s) -

Hua Shen,

Kosei Eguchi,

Nozomu Kono,

Katsuhito Fujiu,

Sahohime Matsumoto,

Munehiko Shibata,

Yumiko Tanaka,

Issei Komuro,

Hiroyuki Arai,

Ryozo Nagai,

Ichiro Manabe

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.302099

Subject(s) - neointima , proinflammatory cytokine , downregulation and upregulation , microbiology and biotechnology , nadph oxidase , medicine , endocrinology , chemistry , biology , inflammation , reactive oxygen species , biochemistry , immunology , stent , restenosis , gene

Obesity is a major risk factor of atherosclerotic cardiovascular disease. Circulating free fatty acid levels are known to be elevated in obese individuals and, along with dietary saturated fatty acids, are known to associate with cardiovascular events. However, little is known about the molecular mechanisms by which free fatty acids are linked to cardiovascular disease.

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