Maternal Hypercholesterolemia in Pregnancy Associates With Umbilical Vein Endothelial Dysfunction | Zendy

Andrea Leiva | Zendy; Camila Diez de Medina | Zendy; Rocío Salsoso | Zendy; Tamara Sáez | Zendy; Sebastián San Martín | Zendy; Fernando Abarzúa | Zendy; Marcelo Farías | Zendy; Enrique GuzmánGutiérrez | Zendy; Fabián Pardo | Zendy; Luis Sobrevía | Zendy

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Maternal Hypercholesterolemia in Pregnancy Associates With Umbilical Vein Endothelial Dysfunction

Author(s) -

Andrea Leiva,

Camila Diez de Medina,

Rocío Salsoso,

Tamara Sáez,

Sebastián San Martín,

Fernando Abarzúa,

Marcelo Farías,

Enrique GuzmánGutiérrez,

Fabián Pardo,

Luis Sobrevía

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301987

Subject(s) - enos , medicine , endocrinology , umbilical vein , arginase , endothelial dysfunction , arginine , nitric oxide , fetus , offspring , chemistry , biology , amino acid , nitric oxide synthase , pregnancy , biochemistry , in vitro , genetics

Human pregnancy that courses with maternal supraphysiological hypercholesterolemia (MSPH) correlates with atherosclerotic lesions in fetal arteries. It is known that hypercholesterolemia associates with endothelial dysfunction in adults, a phenomenon where nitric oxide (NO) and arginase are involved. However, nothing is reported on potential alterations in the fetoplacental endothelial function in MSPH. The aim of this study was to determine whether MSPH alters fetal vascular reactivity via endothelial arginase/urea and L-arginine transport/NO signaling pathways.

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