Apolipoprotein A-IV Expression in Mouse Liver Enhances Triglyceride Secretion and Reduces Hepatic Lipid Content by Promoting Very Low Density Lipoprotein Particle Expansion | Zendy

Melissa VerHague | Zendy; Dongmei Cheng | Zendy; Richard B. Weinberg | Zendy; Gregory S. Shelness | Zendy

Open Access

Apolipoprotein A-IV Expression in Mouse Liver Enhances Triglyceride Secretion and Reduces Hepatic Lipid Content by Promoting Very Low Density Lipoprotein Particle Expansion

Author(s) -

Melissa VerHague,

Dongmei Cheng,

Richard B. Weinberg,

Gregory S. Shelness

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301948

Subject(s) - medicine , endocrinology , steatosis , apolipoprotein b , lipogenesis , lipoprotein , triglyceride , chemistry , knockout mouse , secretion , biology , cholesterol , lipid metabolism , receptor

Previous studies demonstrated that apolipoprotein A-IV (apoA-IV) promotes apoB lipoprotein-mediated triglyceride (TG) secretion in transfected enterocytes and hepatoma cells; however, evidence for a role in lipid transport in vivo is lacking. Using mouse models, we explored the role of apoA-IV in hepatic very low density lipoprotein-mediated lipid efflux under conditions that promote hepatic steatosis.

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