Age-Related Changes in Aortic Valve Hemostatic Protein Regulation | Zendy

Liezl R. Balaoing | Zendy; Allison Post | Zendy; Huiwen Liu | Zendy; Kyung Taeck Minn | Zendy; K. Jane GrandeAllen | Zendy

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Age-Related Changes in Aortic Valve Hemostatic Protein Regulation

Author(s) -

Liezl R. Balaoing,

Allison Post,

Huiwen Liu,

Kyung Taeck Minn,

K. Jane GrandeAllen

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301936

Subject(s) - aortic valve , von willebrand factor , calcification , endothelial stem cell , heart valve , endothelium , medicine , extracellular matrix , plasminogen activator , tissue plasminogen activator , endocrinology , biology , platelet , microbiology and biotechnology , in vitro , biochemistry

Although valvular endothelial cells have unique responses compared with vascular endothelial cells, valvular regulation of hemostasis is not well-understood. Heart valves remodel throughout a person's lifetime, resulting in changes in extracellular matrix composition and tissue mechanical properties that may affect valvular endothelial cell hemostatic function. This work assessed valvular endothelial cell regulation of hemostasis in situ and in vitro as a function of specimen age.

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