Adenosine Monophosphate–Activated Protein Kinase-α2 Deficiency Promotes Vascular Smooth Muscle Cell Migration via S-Phase Kinase–Associated Protein 2 Upregulation and E-Cadherin Downregulation | Zendy

Ping Song | Zendy; Yanhong Zhou | Zendy; Kathleen A. Coughlan | Zendy; Xiaoyan Dai | Zendy; Hairong Xu | Zendy; Benoı̂t Viollet | Zendy; Ming-Hui Zou | Zendy

Open Access

Adenosine Monophosphate–Activated Protein Kinase-α2 Deficiency Promotes Vascular Smooth Muscle Cell Migration via S-Phase Kinase–Associated Protein 2 Upregulation and E-Cadherin Downregulation

Author(s) -

Ping Song,

Yanhong Zhou,

Kathleen A. Coughlan,

Xiaoyan Dai,

Hairong Xu,

Benoı̂t Viollet,

Ming-Hui Zou

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301869

Subject(s) - ampk , protein kinase a , microbiology and biotechnology , vascular smooth muscle , downregulation and upregulation , chemistry , biology , kinase , endocrinology , biochemistry , smooth muscle , gene

Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are critical events in the progression of several vasculopathologies. Adenosine monophosphate-activated protein kinase (AMPK) has been shown to play a pivotal role in cellular proliferation and migration. However, the roles of AMPK in VSMC migration and its underlying molecular mechanisms remain elusive.

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