Bis(Monoacylglycero)Phosphate Accumulation in Macrophages Induces Intracellular Cholesterol Redistribution, Attenuates Liver-X Receptor/ATP-Binding Cassette Transporter A1/ATP-Binding Cassette Transporter G1 Pathway, and Impairs Cholesterol Efflux | Zendy

Céline LuquainCostaz | Zendy; Étienne Lefai | Zendy; Maud Arnal-Levron | Zendy; Daria Markina | Zendy; Shota Sakaï | Zendy; Vanessa Euthine | Zendy; Asami Makino | Zendy; Michel Guichardant | Zendy; Shizuya Yamashita | Zendy; Toshihide Kobayashi | Zendy; Michel Lagarde | Zendy; Philippe Moulin | Zendy; Isabelle DeltonVandenbroucke | Zendy

Open Access

Bis(Monoacylglycero)Phosphate Accumulation in Macrophages Induces Intracellular Cholesterol Redistribution, Attenuates Liver-X Receptor/ATP-Binding Cassette Transporter A1/ATP-Binding Cassette Transporter G1 Pathway, and Impairs Cholesterol Efflux

Author(s) -

Céline LuquainCostaz,

Étienne Lefai,

Maud Arnal-Levron,

Daria Markina,

Shota Sakaï,

Vanessa Euthine,

Asami Makino,

Michel Guichardant,

Shizuya Yamashita,

Toshihide Kobayashi,

Michel Lagarde,

Philippe Moulin,

Isabelle DeltonVandenbroucke

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301857

Subject(s) - atp binding cassette transporter , efflux , transporter , intracellular , cholesterol , biochemistry , abca1 , atp binding cassette transporter 1 , receptor , biology , chemistry , microbiology and biotechnology , gene

Endosomal signature phospholipid bis(monoacylglycero)phosphate (BMP) has been involved in the regulation of cellular cholesterol homeostasis. Accumulation of BMP is a hallmark of lipid storage disorders and was recently reported as a noticeable feature of oxidized low-density lipoprotein-laden macrophages. This study was designed to delineate the consequences of macrophage BMP accumulation on intracellular cholesterol distribution, metabolism, and efflux and to unravel the underlying molecular mechanisms.

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