Transforming Growth Factor-β–Activated Kinase 1 Regulates Angiogenesis via AMP-Activated Protein Kinase-α1 and Redox Balance in Endothelial Cells | Zendy

Nina Zippel | Zendy; Randa Abdel Malik | Zendy; Timo Frömel | Zendy; Rüdiger Popp | Zendy; Elke Bess | Zendy; Boris Strilić | Zendy; Nina Wettschureck | Zendy; Ingrid Fleming | Zendy; Beate Fißlthaler | Zendy

Open Access

Transforming Growth Factor-β–Activated Kinase 1 Regulates Angiogenesis via AMP-Activated Protein Kinase-α1 and Redox Balance in Endothelial Cells

Author(s) -

Nina Zippel,

Randa Abdel Malik,

Timo Frömel,

Rüdiger Popp,

Elke Bess,

Boris Strilić,

Nina Wettschureck,

Ingrid Fleming,

Beate Fißlthaler

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301848

Subject(s) - microbiology and biotechnology , vascular endothelial growth factor a , vascular endothelial growth factor , angiogenesis , protein kinase a , chemistry , ampk , protein kinase b , endothelial stem cell , kinase , cancer research , biology , signal transduction , biochemistry , in vitro , vegf receptors

Transforming growth factor-β-activated kinase 1 (TAK1) is a mitogen-activated protein 3-kinase and an AMP-activated protein kinase (AMPK) kinase in some cell types. Although TAK1(-/-) mice display defects in developmental vasculogenesis, the role of TAK1 in endothelial cells has not been investigated in detail.

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