Molecular Imaging Reveals Rapid Reduction of Endothelial Activation in Early Atherosclerosis With Apocynin Independent of Antioxidative Properties | Zendy

Elham Khanicheh | Zendy; Yue Qi | Zendy; Aris Xie | Zendy; Martina Mitterhuber | Zendy; Lifen Xu | Zendy; Michika Mochizuki | Zendy; Youssef Daali | Zendy; Vincent Jaquet | Zendy; Karl-Heinz Krause | Zendy; Zaverio M. Ruggeri | Zendy; Gabriela M. Kuster | Zendy; Jonathan R. Lindner | Zendy; Beat A. Kaufmann | Zendy

Open Access

Molecular Imaging Reveals Rapid Reduction of Endothelial Activation in Early Atherosclerosis With Apocynin Independent of Antioxidative Properties

Author(s) -

Elham Khanicheh,

Yue Qi,

Aris Xie,

Martina Mitterhuber,

Lifen Xu,

Michika Mochizuki,

Youssef Daali,

Vincent Jaquet,

Karl-Heinz Krause,

Zaverio M. Ruggeri,

Gabriela M. Kuster,

Jonathan R. Lindner,

Beat A. Kaufmann

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301710

Subject(s) - apocynin , nadph oxidase , reactive oxygen species , nicotinamide adenine dinucleotide phosphate , superoxide , chemistry , pharmacology , cell adhesion molecule , oxidative stress , western blot , biochemistry , medicine , oxidase test , immunology , enzyme , gene

Antioxidative drugs continue to be developed for the treatment of atherosclerosis. Apocynin is an nicotinamide adenine dinucleotide phosphate oxidase inhibitor with anti-inflammatory properties. We used contrast-enhanced ultrasound molecular imaging to assess whether short-term apocynin therapy in atherosclerosis reduces vascular oxidative stress and endothelial activation

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