Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State | Zendy

Julian Ilcheff Borissoff | Zendy; Ivo A. Joosen | Zendy; Mathijs O. Versteylen | Zendy; Alexander Brill | Zendy; Tobias A. Fuchs | Zendy; A.S. Savchenko | Zendy; Maureen Gallant | Zendy; Kimberly Martinod | Zendy; Hugo Ten Cate | Zendy; Leonard Hofstra | Zendy; Harry J.G.M. Crijns | Zendy; Denisa D. Wagner | Zendy; Bas Kietselaer | Zendy

Open Access

Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State

Author(s) -

Julian Ilcheff Borissoff,

Ivo A. Joosen,

Mathijs O. Versteylen,

Alexander Brill,

Tobias A. Fuchs,

A.S. Savchenko,

Maureen Gallant,

Kimberly Martinod,

Hugo Ten Cate,

Leonard Hofstra,

Harry J.G.M. Crijns,

Denisa D. Wagner,

Bas Kietselaer

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301627

Subject(s) - neutrophil extracellular traps , medicine , myeloperoxidase , coronary atherosclerosis , coronary artery disease , cardiology , inflammation

Aberrant neutrophil activation occurs during the advanced stages of atherosclerosis. Once primed, neutrophils can undergo apoptosis or release neutrophil extracellular traps. This extracellular DNA exerts potent proinflammatory, prothrombotic, and cytotoxic properties. The goal of this study was to examine the relationships among extracellular DNA formation, coronary atherosclerosis, and the presence of a prothrombotic state.

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