Aortic Remodeling After Transverse Aortic Constriction in Mice Is Attenuated With AT 1 Receptor Blockade | Zendy

Shao-Qing Kuang | Zendy; Liang Geng | Zendy; Siddharth K. Prakash | Zendy; Jiu-Mei Cao | Zendy; Steven Guo | Zendy; Carlos Villamizar | Zendy; Callie S. Kwartler | Zendy; Andrew M. Peters | Zendy; Allan R. Brasier | Zendy; Dianna M. Milewicz | Zendy

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Aortic Remodeling After Transverse Aortic Constriction in Mice Is Attenuated With AT ₁ Receptor Blockade

Author(s) -

Shao-Qing Kuang,

Liang Geng,

Siddharth K. Prakash,

Jiu-Mei Cao,

Steven Guo,

Carlos Villamizar,

Callie S. Kwartler,

Andrew M. Peters,

Allan R. Brasier,

Dianna M. Milewicz

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301624

Subject(s) - losartan , angiotensin ii , ascending aorta , aorta , medicine , endocrinology , receptor

Although hypertension is the most common risk factor for thoracic aortic diseases, it is not understood how increased pressures on the ascending aorta lead to aortic aneurysms. We investigated the role of angiotensin II type 1 receptor activation in ascending aortic remodeling in response to increased biomechanical forces using a transverse aortic constriction (TAC) mouse model.

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