Open AccessElevated Prothrombin Promotes Venous, but Not Arterial, Thrombosis in Mice
Author(s) -
Maria M. Aleman,
Bethany L. Walton,
James R. Byrnes,
Jianguo Wang,
Matthew J. Heisler,
Kellie R. Machlus,
Brian C. Cooley,
Alisa S. Wolberg
Publication year - 2013
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.113.301607
Subject(s) - medicine , thrombosis , fibrin , thrombin , inferior vena cava , thromboplastin , platelet , ex vivo , venous thrombosis , tissue factor , endocrinology , cardiology , in vivo , coagulation , immunology , biology , microbiology and biotechnology
Individuals with elevated prothrombin, including those with the prothrombin G20210A mutation, have increased risk of venous thrombosis. Although these individuals do not have increased circulating prothrombotic biomarkers, their plasma demonstrates increased tissue factor-dependent thrombin generation in vitro. The objectives of this study were to determine the pathological role of elevated prothrombin in venous and arterial thrombosis in vivo, and distinguish thrombogenic mechanisms in these vessels.
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