Sirolimus Stimulates Vascular Stem/Progenitor Cell Migration and Differentiation Into Smooth Muscle Cells via Epidermal Growth Factor Receptor/Extracellular Signal–Regulated Kinase/β-Catenin Signaling Pathway | Zendy

Mei Mei Wong | Zendy; Bernhard Winkler | Zendy; Eirini Karamariti | Zendy; Xiaocong Wang | Zendy; Baoqi Yu | Zendy; Russell Simpson | Zendy; Ting Chen | Zendy; Andriani Margariti | Zendy; Qingbo Xu | Zendy

Open Access

Sirolimus Stimulates Vascular Stem/Progenitor Cell Migration and Differentiation Into Smooth Muscle Cells via Epidermal Growth Factor Receptor/Extracellular Signal–Regulated Kinase/β-Catenin Signaling Pathway

Author(s) -

Mei Mei Wong,

Bernhard Winkler,

Eirini Karamariti,

Xiaocong Wang,

Baoqi Yu,

Russell Simpson,

Ting Chen,

Andriani Margariti,

Qingbo Xu

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301595

Subject(s) - progenitor cell , microbiology and biotechnology , neointima , cancer research , stem cell , epidermal growth factor , biology , vascular endothelial growth factor , endothelial progenitor cell , medicine , receptor , restenosis , biochemistry , stent , vegf receptors

Sirolimus-eluting stent therapy has achieved considerable success in overcoming coronary artery restenosis. However, there remain a large number of patients presenting with restenosis after the treatment, and the source of its persistence remains unclarified. Although recent evidence supports the contribution of vascular stem/progenitor cells in restenosis formation, their functional and molecular responses to sirolimus are largely unknown.

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