Lysine Acetyltransferase PCAF Is a Key Regulator of Arteriogenesis | Zendy

A.J.N.M. Bastiaansen | Zendy; M.M. Ewing | Zendy; Hetty C. de Boer | Zendy; Tineke C. van der Pouw Kraan | Zendy; Margreet R. de Vries | Zendy; Erna A Peters | Zendy; S. Welten | Zendy; Ramon Arens | Zendy; Scott M. Moore | Zendy; James E. Faber | Zendy; J. Wouter Jukema | Zendy; Jaap F. Hamming | Zendy; A. Yaël Nossent | Zendy; Paul H.A. Quax | Zendy

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Lysine Acetyltransferase PCAF Is a Key Regulator of Arteriogenesis

Author(s) -

A.J.N.M. Bastiaansen,

M.M. Ewing,

Hetty C. de Boer,

Tineke C. van der Pouw Kraan,

Margreet R. de Vries,

Erna A Peters,

S. Welten,

Ramon Arens,

Scott M. Moore,

James E. Faber,

J. Wouter Jukema,

Jaap F. Hamming,

A. Yaël Nossent,

Paul H.A. Quax

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301579

Subject(s) - arteriogenesis , pcaf , regulator , lysine , key (lock) , acetyltransferase , computer science , biology , cancer research , biochemistry , acetylation , gene , computer security , angiogenesis , amino acid

Therapeutic arteriogenesis, that is, expansive remodeling of preexisting collaterals, using single-action factor therapies has not been as successful as anticipated. Modulation of factors that act as a master switch for relevant gene programs may prove more effective. Transcriptional coactivator p300-CBP-associated factor (PCAF) has histone acetylating activity and promotes transcription of multiple inflammatory genes. Because arteriogenesis is an inflammation-driven process, we hypothesized that PCAF acts as multifactorial regulator of arteriogenesis.

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