Molecular Basis of Antiangiogenic Thrombospondin-1 Type 1 Repeat Domain Interactions With CD36 | Zendy

Philip A. Klenotic | Zendy; Richard C. Page | Zendy; Wei Li | Zendy; Joseph Amick | Zendy; Saurav Misra | Zendy; Roy L. Silverstein | Zendy

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Molecular Basis of Antiangiogenic Thrombospondin-1 Type 1 Repeat Domain Interactions With CD36

Author(s) -

Philip A. Klenotic,

Richard C. Page,

Wei Li,

Joseph Amick,

Saurav Misra,

Roy L. Silverstein

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301523

Subject(s) - cd36 , thrombospondin , thrombospondin 1 , biology , angiogenesis , microbiology and biotechnology , chemistry , biochemistry , receptor , genetics , metalloproteinase , enzyme

Antiangiogenic activity of thrombospondin-1 and related proteins is mediated by interactions between thrombospondin type 1 repeat (TSR) domains and the CD36, LIMP-2, Emp sequence homology (CLESH) domain of the endothelial cell receptor CD36. We sought to characterize key molecular determinants of the interaction between thrombospondin-1 TSR domains and the CD36 CLESH domain.

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