Hepatic Cholesterol Homeostasis | Zendy

Allan D. Sniderman | Zendy; Yanqin Qi | Zendy; J. Cheng-I | Zendy; Rui Hao Leo Wang | Zendy; Mark Naples | Zendy; Chris Baker | Zendy; Jing Zhang | Zendy; Khosrow Adeli | Zendy; Robert S. Kiss | Zendy

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Hepatic Cholesterol Homeostasis

Author(s) -

Allan D. Sniderman,

Yanqin Qi,

J. Cheng-I,

Rui Hao Leo Wang,

Mark Naples,

Chris Baker,

Jing Zhang,

Khosrow Adeli,

Robert S. Kiss

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301517

Subject(s) - very low density lipoprotein , cholesterol , hepatocyte , intermediate density lipoprotein , reverse cholesterol transport , lipoprotein , chylomicron , chemistry , sterol o acyltransferase , ldl receptor , medicine , endocrinology , liver x receptor , biochemistry , biology , nuclear receptor , in vitro , gene , transcription factor

The hypothesis that cholesterol that enters the cell within low-density lipoprotein (LDL) particles rapidly equilibrates with the regulatory pool of intracellular cholesterol and maintains cholesterol homeostasis by reducing cholesterol and LDL receptor synthesis was validated in the fibroblast but not in the hepatocyte. Accordingly, the present studies were designed to compare the effects of cholesterol that enters the hepatocyte within an LDL particle with those of cholesterol that enters via other lipoprotein particles.

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