Aging Impairs Electrical Conduction Along Endothelium of Resistance Arteries Through Enhanced Ca2+-Activated K + Channel Activation | Zendy

Erik J. Behringer | Zendy; Rebecca L. Shaw | Zendy; Erika B. Westcott | Zendy; Matthew J. Socha | Zendy; Steven S. Segal | Zendy

Open Access

Aging Impairs Electrical Conduction Along Endothelium of Resistance Arteries Through Enhanced Ca2+-Activated K ⁺ Channel Activation

Author(s) -

Erik J. Behringer,

Rebecca L. Shaw,

Erika B. Westcott,

Matthew J. Socha,

Steven S. Segal

Publication year - 2013

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.113.301514

Subject(s) - apamin , charybdotoxin , hyperpolarization (physics) , chemistry , membrane potential , biophysics , acetylcholine , conductance , calcium activated potassium channel , potassium channel , medicine , biology , biochemistry , stereochemistry , nuclear magnetic resonance spectroscopy , mathematics , combinatorics

Intercellular conduction of electrical signals underlies spreading vasodilation of resistance arteries. Small- and intermediate-conductance Ca(2+)-activated K(+) channels of endothelial cells serve a dual function by initiating hyperpolarization and modulating electrical conduction. We tested the hypothesis that regulation of electrical signaling by small- and intermediate-conductance Ca(2+)-activated K(+) channels is altered with advancing age.

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